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J Med Virol ; 92(6): 577-583, 2020 06.
Article in English | MEDLINE | ID: covidwho-32888

ABSTRACT

The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]).


Subject(s)
Coronavirus Infections/epidemiology , Coronavirus Infections/physiopathology , Pandemics , Patient Discharge/statistics & numerical data , Pneumonia, Viral/epidemiology , Pneumonia, Viral/physiopathology , Betacoronavirus/pathogenicity , Biomarkers/blood , C-Reactive Protein/metabolism , COVID-19 , China/epidemiology , Coronavirus Infections/diagnosis , Coronavirus Infections/mortality , Cough/blood , Cough/diagnosis , Cough/physiopathology , Dyspnea/blood , Dyspnea/diagnosis , Dyspnea/physiopathology , Female , Fever/blood , Fever/diagnosis , Fever/physiopathology , Humans , Incidence , Lymphopenia/blood , Lymphopenia/diagnosis , Lymphopenia/physiopathology , Male , Pneumonia, Viral/diagnosis , Pneumonia, Viral/mortality , SARS-CoV-2 , Sex Factors , Survival Analysis
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